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Management of prosthetic joint infections (PJI) involves surgery and antimicrobial therapy, although the best approach for each intervention remains unclear. To assess the safety and efficacy of 6 versus 12 weeks of antibiotic therapy for PJI, French investigators conducted a randomized, open-label noninferiority trial. Among 404 participants, 41% had debridement with implant retention, 37% had one-stage implant exchange, and 22% had two-stage implant exchange. The primary pathogens were Staphylococcus aureus (38%, 6-week; 30%, 12-week) and coagulase-negative staphylococci (30%, 6-week; 35%, 12-week). Median duration of intravenous antibiotic therapy was 9 days in both groups whereas median total duration was 42 days (6-week group) and 84 d…