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A new study calls into question the long-term safety of a 1-hour high-sensitivity cardiac troponin T (hs-cTnT) protocol — with clinicians unmasked to lower levels — in evaluating suspected acute coronary syndrome (ACS). One-year results of the RAPID-TnT trial were presented on May 16, 2021, at the Annual Scientific Session of the American College of Cardiology.
Nearly 3300 participants with suspected ACS and without obvious ischemia on electrocardiogram were randomized to a strategy of testing troponin T levels at baseline and 1 hour (0/1-hour) or a standard strategy of testing at baseline and 3 hours (0/3-hour). With the 0/1-hour protocol, clinicians were unmasked to hs-cTnT levels ≤29 ng/L, whereas with the 0/3-hour protocol, clinicians re…