Do Neutralizing Antibody Titers Foretell Immune Protection Against COVID-19?

In an analysis of eight studies, normalized neutralizing antibody titers were highly correlated with vaccine efficacy and apparent protection after natural infection.

Recognizing the immune correlates of protection against SARS-CoV-2 infection is a key goal in surmounting the COVID-19 pandemic. One approach is to examine levels of neutralizing antibody titers with in vitro assays after vaccination or natural infection.

Using data from seven phase 3 vaccine studies and one convalescent study, investigators normalized neutralization titers to the mean convalescent titer across all studies. Compared with the protective efficacy reported in these studies, a highly significant correlation between normalized convalescent titer and vaccine efficacy was found (r=0.905). In a logistic model, the neutralization level to achieve 50% protection against viral infection was 20.2% of the mean convalescent titer. To prev…

Reviewing Author

Neil M. Ampel, MD

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Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesCoccidioidomycosis Study Group (Past President, Secretary, Treasurer)

Neil M. Ampel, MD

Disclosures

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesCoccidioidomycosis Study Group (Past President, Secretary, Treasurer)

Do Neutralizing Antibody Titers Foretell Immune Protection Against COVID-19?

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Reviewing Author