Brain Metabolic Patterns and REM Sleep Behavior Disorder

Brain metabolic patterns on FDG-PET imaging may be a distinguishing feature in those with idiopathic REM sleep behavior disorder who will develop Parkinson disease.

REM sleep behavior disorder (RBD) may occur years before the onset of cognitive and motor symptoms in Parkinson disease (PD), multiple system atrophy (MSA), or dementia with Lewy bodies (DLB). Researchers conducted this prospective cohort study to determine whether brain metabolic patterns could be distinguished among healthy controls, patients with polysomnography-confirmed idiopathic RBD (iRBD), Parkinson disease patients with a pre-morbid history of RBD based on validated questionnaires (PD-RBD), and treated Parkinson disease (PD) patients. Resting ¹⁸ F-fluorodeoxyglucose positron emission tomography (FDG-PET) patterns were derived from those with PD-RBD (PDRBD pattern) and those with treated PD (PD pattern). Patients also underwent olfa…

Reviewing Author

Jennifer Rose V. Molano, MD

Disclosures

Grant/Research SupportNational Center for Advancing Translational Science – Cincinnati Center for Clinical and Translational Science and Training

Editorial BoardsBrain & Life

Jennifer Rose V. Molano, MD

Disclosures

Grant/Research SupportNational Center for Advancing Translational Science – Cincinnati Center for Clinical and Translational Science and Training

Editorial BoardsBrain & Life

Brain Metabolic Patterns and REM Sleep Behavior Disorder

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Reviewing Author