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Studies of patients who have recovered from SARS-CoV-2 infection but have persistent symptoms, so called “long-haulers,” have ranged widely in size, quality, and methodology, leading to confusion about the prevalence and types of persistent symptoms. In this meta-analysis, researchers identified nearly 2000 studies that addressed persistent post–COVID-19 symptoms; 45 studies, with a total of ≈10,000 patients and 84 discrete symptoms, were deemed suitable for analysis. The studies were highly heterogeneous, including wide variation in the severity and nature of the original infections.
Nearly three quarters of patients reported at least one persistent symptom for a mean or median of 2 to 4 months; and some symptoms were reported to persist fo…