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Iron deficiency anemia (IDA) is the most common cause of anemia worldwide, and it often affects pregnant women due to increased demands on iron stores. There are now many different formulations of oral and parenteral iron replacement, but their effectiveness has not been compared.
These investigators conducted a systematic review and network meta-analysis of various iron formulations used in the treatment of IDA during pregnancy. The analysis included 53 trials from 22 countries published between 1969 and 2020. The trials included 9145 women.
Key findings included:
Baseline hemoglobin values ranged from 6 to 11 g/dL, with most women having values between 7.0 and 9.9 g/dL.
When compared to the reference of oral ferrous sulfate, both intravenous …