How Well Does COVID-19 Vaccination Protect Against the Delta Variant?

In a U.K. observational study, two doses of the Pfizer-BioNTech and Oxford/AstraZeneca vaccines had 88% and 67% effectiveness, respectively, against the Delta variant.

As the Delta (B.1.617.2) SARS-CoV-2 variant fuels a global surge in COVID-19, an urgent clinical question concerns how effective the available vaccines are against this variant. Using data from the U.K. National Health Service, investigators addressed this question for the Pfizer-BioNTech (BNT162b2) and Oxford/AstraZeneca (ChAdOx1) vaccines. In a test-negative case-control study, they compared vaccination status in patients reporting COVID-19 symptoms who tested positive (cases) or negative (controls) for COVID-19. In a secondary analysis, the relative incidence of infections with the Alpha (B.1.1.7) and Delta variants was estimated in both vaccinated and unvaccinated individuals.

Between November 20, 2020, and May 16, 2021, a total of 19,10…

Reviewing Author

Richard T. Ellison III, MD

Disclosures

Consult/Advisory BoardAcurx Pharmaceuticals, LLC;

Grant/Research SupportDoctors Company Foundation, Massachusetts Department of Public Health

Richard T. Ellison III, MD

Disclosures

Consult/Advisory BoardAcurx Pharmaceuticals, LLC;

Grant/Research SupportDoctors Company Foundation, Massachusetts Department of Public Health

How Well Does COVID-19 Vaccination Protect Against the Delta Variant?

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Reviewing Author