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Steroids are typical first-line choices for the treatment of immune thrombocytopenia; however, adverse events and treatment failures are common, and alternative front-line therapies are needed. In the multicenter U.K. FLIGHT trial, 120 patients with a platelet count <30×109/L were randomized to mycophenolate mofetil plus steroids (prednisolone or dexamethasone) versus steroids alone. The primary endpoint was treatment failure, defined as platelet count <30×109/L and need for a second-line treatment.
Mean age was 54 years, 54% were male, and mean platelet count was 7×109/L. Prednisolone was the most commonly used steroid in both treatment groups and was dosed at 1 mg/kg for 4 days, followed by 40 mg daily for 2 weeks, with further tapering (2…