Malaria Vaccine + Chemoprophylaxis = The Best Approach

In an African trial, vaccination against malaria was not inferior to chemoprevention for preventing malaria cases and deaths; however, combining the two strategies worked best.

No single intervention is highly effective in malaria control. Are combinations better? In a double-blind trial in Burkina Faso and Mali, investigators evaluated seasonal vaccination compared with chemoprevention and asked whether a combination worked better than either intervention alone. They randomized >6000 children (age range, 5–17 months) to receive chemoprevention (sulfadoxine-pyrimethamine and amodiaquine; four monthly courses), malaria vaccine (RTS,S/AS01g), or both interventions. Children in the vaccine groups received five RTS,S/ASO1g doses from 2017 through 2019. Children in the chemoprevention-only group received rabies vaccine or hepatitis A vaccine instead of malaria vaccine. All participants received insecticide-treated bed …

Reviewing Author

Mary E. Wilson, MD

Disclosures

Consultant/Advisory BoardOneHealthTrust (formerly Center for Disease Dynamics, Economics, and Policy); Global Health Institute, University of Wisconsin

RoyaltiesUpToDate

Editorial BoardsJournal of Travel Medicine

Mary E. Wilson, MD

Disclosures

Consultant/Advisory BoardOneHealthTrust (formerly Center for Disease Dynamics, Economics, and Policy); Global Health Institute, University of Wisconsin

RoyaltiesUpToDate

Editorial BoardsJournal of Travel Medicine

Malaria Vaccine + Chemoprophylaxis = The Best Approach

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Reviewing Author