USPSTF Reaffirms Recommendations for Low-Dose Aspirin to Prevent Preeclampsia

Background

In 2014, the USPSTF recommended low-dose aspirin after 12 weeks' gestation for pregnant women at high risk for preeclampsia (NEJM JW Womens Health Oct 2014 and Ann Intern Med 2014; 161:819). In this 2021 update, researchers incorporated data from several newer trials, including the large, multicenter ASPRE trial (NEJM JW Gen Med Aug 15 2017 and N Engl J Med 2017; 377:613).

Key Recommendations

• The Task Force continues to recommend low-dose aspirin (81 mg/day) after 12 weeks' gestation as a preventive measure for women at high risk for preeclampsia. (B recommendation; moderate-certainty evidence of substantial net benefit)

• As data on optimal risk prediction for preecl…