Low-Level HIV Viremia Related to Lower Cumulative Adherence to Antiretroviral Therapy

In a study of patients receiving a tenofovir-containing regimen, lower TDF-diphosphate levels doubled risk for low-level HIV viremia.

Low-level HIV viremia (LLV; typically defined as HIV RNA above a specific lower limit of detection and below threshold for virologic failure) is frequently encountered in clinical practice, but its cause and ramifications are unclear. Investigators at the University of Colorado enrolled persons living with HIV (PLWH) receiving a regimen containing tenofovir disoproxil fumarate (TDF) to assess the relation between degree of viremia (categorized as <20 [i.e., reference], ≥20–<200, ≥200–<1000, and >1000 copies/ml) and cumulative ART adherence as indicated by levels of TDF-diphosphate (TDF-DP) in dried bloodspots (DBS). The authors utilized three tiers of TDF-DP previously shown to predict subsequent viremia (≥1650, 800–1650, and <800 fmol/bloo…

Reviewing Author

Keith Henry, MD

Disclosures

Consultant/Advisory BoardViiV Advisory Board

Editorial BoardsJAIDS: Journal of Acquired Immune Deficiency Syndromes

Keith Henry, MD

Disclosures

Consultant/Advisory BoardViiV Advisory Board

Editorial BoardsJAIDS: Journal of Acquired Immune Deficiency Syndromes

Low-Level HIV Viremia Related to Lower Cumulative Adherence to Antiretroviral Therapy

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Reviewing Author