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Gastroenteropancreatic (GEP) neuroendocrine tumors (NETs) are a rare, heterogenous group of diseases with a natural history ranging from indolent to highly aggressive. There is evidence of increased incidence of these tumors from recent retrospective series. Investigators now report a cohort study evaluating epidemiologic and survival data in nearly 44,000 patients with GEP NETs from 1975 to 2015 from the U.S. Surveillance, Epidemiology, and End Results (SEER) Program.
Incidence was similar in men and women, with age-adjusted incidence rates increasing over time. Rates increased similarly across races and some ethnicities but were more stable in American Indian and Alaska natives. Rates of increase were highest for localized and for grade 1 …