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Transarterial Yttrium-90 radioembolization (TARE) is a treatment option for patients with refractory colorectal cancer and unresectable liver-confined metastases. In a recent randomized trial, combining regional radioembolization with chemotherapy in the first-line treatment of metastatic colorectal cancer failed to improve survival over chemotherapy alone (NEJM JW Oncol Hematol Nov 2017 and Lancet Oncol 2017; 18:1159)
Investigators now report results of an industry-sponsored, multicenter, open-label randomized phase 3 trial evaluating the addition of TARE to second-line chemotherapy in metastatic colorectal cancer with liver-dominant metastatic disease. Of 428 patients randomized, median age was 61, 36% had the primary tumor in place, 26% h…