Loading...
This is the fourth update to these guidelines; the third update was published in 2017 (NEJM JW Gen Med Mar 1 2017 and Intensive Care Med 2017; 43:304).
The recommendation for an initial fluid bolus of 30 mL/kg was downgraded from a strong recommendation to a weak recommendation, based on the low quality of evidence. However, resuscitation should start immediately.
Balanced crystalloid solution (e.g., lactated Ringer's solution) should be used (rather than normal saline) for resuscitation.
Administration of vasopressors should be initiated via peripheral access, as opposed to waiting for placement of central…