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Studies with various limitations generally have shown that high sodium intake and low potassium intake are associated with higher risk for hypertension and adverse cardiovascular (CV) events. To provide more-robust evidence, researchers combined data from six prospective cohort studies in which multiple 24-hour urine collections for sodium and potassium (average, 3–4 collections per participant) were used to estimate intake. Nearly 11,000 adults (mean age, 52) with no evidence of CV or kidney disease were followed for a median of 9 years.
The primary CV outcome (i.e., myocardial infarction, stroke, or coronary revascularization) occurred in about 6% of participants. In analyses adjusted for potentially confounding variables, this outcome was…