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Most behavioral and pharmacologic approaches to obesity treatment have limited efficacy and sustainability, and bariatric surgery — although more effective and sustainable — is invasive and risky. Fluid-filled, space-occupying intragastric balloons (IGBs), which are inserted endoscopically and left in place for 6 months, are associated with loss of as much as 10% of body weight but have been limited by patients' intolerance and regain of weight after removal. In a manufacturer-funded study, researchers randomized 288 obese adults (body-mass index, 30–40 kg/m2) to lifestyle changes with or without endoscopically adjustable IGBs. At prespecified intervals, balloon volume was increased for added treatment effect or decreased to improve tolerab…