Analysis of SARS-CoV-2 Infection Risk After Two Doses of Pfizer-BioNTech mRNA Vaccine

In a study in Israel, likelihood of infection gradually increased beginning 90 days after the second dose.

With multiple waves of the COVID-19 pandemic evolving, it has become evident that individuals can become infected despite complete vaccination. In an analysis of nationwide data in Israel, researchers used a test negative study design to assess risk for infection in 83,057 adults after complete immunization with two doses of Pfizer-BioNTech BNT162b2 mRNA vaccine. Those with COVID-19 diagnosed before the study period were excluded.

Between May 15 and September 17, 2021, 9.6% of participants tested positive for SARS-CoV-2 by RT-PCR. Of 113 isolates, sequencing revealed the Delta variant in 93.0%. Likelihood of testing positive increased significantly with time since the second vaccine dose. Compared with the reference period (21–89 days after …

Reviewing Author

Thomas Glück, MD

Disclosures

Editorial BoardsConsilium Infectiorum by InfectoPharm, Infection

Thomas Glück, MD

Disclosures

Editorial BoardsConsilium Infectiorum by InfectoPharm, Infection

Analysis of SARS-CoV-2 Infection Risk After Two Doses of Pfizer-BioNTech mRNA Vaccine

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Reviewing Author