Eliminating Gonorrhea with a Vaccine?

Mathematical modeling indicates that a vaccine with 100% protective or transmission efficacy could reduce gonorrhea prevalence by ≥90% within 2 years.

The World Health Organization has set a goal of 2030 for reducing the global incidence of gonorrhea by 90% — and vaccination is one way to achieve this. A recent study found that immunization with the outer membrane vesicle meningococcal B vaccine had a vaccine effectiveness against gonorrhea of 31%, suggesting that designing a specific vaccine against Neisseria gonorrhoeae is possible. To explore the effects of such a vaccine, Australian researchers developed a mathematical model to simulate N. gonorrhoeae transmission among 10,000 urban men who have sex with men (MSM; age range, 16–80).

Estimating that 30% of MSM will be vaccinated at diagnosis of sexually transmitted disease and that the vaccine acts equally at all sites of infection (ure…

Reviewing Author

Neil Ampel, MD

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Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesCoccidioidomycosis Study Group (Past President, Secretary, Treasurer)

Neil Ampel, MD

Disclosures

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesCoccidioidomycosis Study Group (Past President, Secretary, Treasurer)

Eliminating Gonorrhea with a Vaccine?

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Reviewing Author