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Cardiac troponin T (cTnT) is associated with mortality in chronic kidney disease (CKD), even in the absence of acute coronary syndromes. But can longitudinally measured levels of high-sensitivity troponin T (hs-cTnT) help identify those at highest risk?
In an observational, prospective cohort study from Sweden of 176 individuals aged 65 or older with stage 4 or 5 CKD not yet on dialysis, investigators collected serial hs-cTnT samples (median number, 6) over a median follow-up of 2.4 years. The overall 5-year survival rate was 57%. One third of the cohort transitioned to dialysis. Multiple parameters predicted mortality, including longitudinally measured hs-cTnT (hazard ratio, 3.3 per standard deviation increase), the slope of the hs-cTnT tra…