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In this cross-sectional assessment of 816 unvaccinated healthy adults (mean age, 48) recruited on social media, researchers assessed antibody status arising from SARS-CoV-2 infection rather than from vaccination. Participants were categorized as follows, with 250 to 300 people in each group: (1) test-confirmed COVID-19 (“COVID-confirmed”), (2) belief that they were infected but no testing (“COVID-unconfirmed”), or (3) belief that they had never been infected and no testing (“no-COVID”). Participants were tested for spike-protein receptor-binding domain antibodies (anti-RBD) with a commercially available test.
Anti-RBD antibodies were found in 99% of COVID-confirmed people, 55% of COVID-unconfirmed people, and 11% of no-COVID people. In the C…