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Measuring arterial oxygen saturation with pulse oximetry might be less accurate in patients with darker skin pigmentation, and the effects of such a difference on patient outcomes is unclear (N Engl J Med 2020; 383:2477). In a retrospective observational study, researchers paired >128,000 pulse oximetry–estimated oxygen saturation (SpO2) measurements with their associated arterial blood gas (ABG)–derived oxygen saturation (SaO2) readings in >26,000 adult intensive care unit (ICU) or surgical inpatients at 3 U.S. academic medical centers.
After adjusting for potential confounders, self-identified Black patients were significantly more likely to have occult hypoxemia (defined as SaO2 <88% despite normal SpO2 [i.e., ≥92%]) during hospitalizatio…