Preserving Ovarian Function in Women with Breast Cancer

In an effort to preserve fertility in women with breast cancer without compromising efforts to reduce the risk of disease recurrence, many strategies have been employed, including the use of gonadotropin-releasing hormone analogs (GnRHa) to make the ovaries quiescent during adjuvant chemotherapy. Two prior studies, POEMS and PROMIS-GIM6, demonstrated that GnRHa administered during adjuvant chemotherapy had a protective effect on ovarian function and reduced the risk of early menopause induced by chemotherapy; however, the sample sizes were modest. Furthermore, prior studies used traditional markers of ovarian function, such as menstrual history, follicle-stimulating hormone (FSH), luteinizing hormone (LH), and inhibin B, which have proven t…