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Spinal cord compression (SCC) remains a true oncologic emergency, as loss of neurologic function has devastating effects on a patient's quality of life. Given the bone tropism of metastatic prostate cancer, it is not surprising that studies report an SCC incidence ranging from 7% to 24%. To explore the utility of early intervention based on spinal magnetic resonance imaging (MRI) findings, investigators in the U.K. conducted an open-label, randomized, controlled, phase 3 study.
Patients with progressive metastatic castration-resistant prostate cancer (mCRPC) with bone metastases, asymptomatic spinal metastases, or both, and with ECOG performance status of 0-2 were randomized to either no MRI or whole-spine screening MRI within one month. Rad…