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Proton-pump inhibitors (PPIs) are consistently among the top 10 medications prescribed in the U.S. Although indications for long-term use are limited, many patients continue to take these medications for years or even decades. This clinical practice update — geared toward generalists — offers considerations for discontinuing PPIs safely.
Note that these recommendations are based on expert opinion, supported by literature review, and thus do not include evidence grades.
Primary care providers should review and document indications for ongoing PPI use regularly. The only definite indications for chronic use (>8 weeks) are complicated gastroesophageal reflu…