Biomarkers as Predictors of Progressive Brain Deterioration in Traumatic Brain Injury

Traumatic brain injury (TBI) has been studied as a cause of progressive brain deterioration and has a strong association with risk for parkinsonism (Biomed Pharmacother 2022; 149:112812). Biomarkers such as glial fibrillary acid protein (GFAP) and neurofilament light have been widely studied in acute brain injury. Nevertheless, biomarker use is limited in chronic phases. Recent studies have shown that these biomarkers can be of great use in identifying neurodegeneration in several neurologic diseases.

In this study, the authors examined the relationship between biomarkers, imaging changes, and functional outcomes months and years following TBI. The analysis included two cohorts with a total of 203 patients, 165 of whom were recruited at 6 mo…