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Evidence indicates that Streptococcus pneumoniae interacts with viruses to cause respiratory disease, suggesting that interventions targeting pneumococci may offer ancillary benefit by preventing virally attributed disease. In 2014, the 13-valent pneumococcal conjugate vaccine (PCV13) was approved by the Advisory Committee for Immunization Practices (ACIP) for individuals aged ≥65 and those aged 19–64 with certain underlying medical conditions or risk factors. In 2021, the ACIP recommended the 20-valent product (PCV20) for these same groups. To examine if PCV13 use in adults is associated with reduced risk for viral respiratory infections, researchers at Kaiser Permanente Southern California conducted a manufacturer-sponsored study from 201…