Observation vs. Surgery for Mild Asymptomatic Primary Hyperparathyroidism

In long-term follow up from a randomized trial, no important outcome differences were noted.

In the largest randomized trial to date of patients with mild asymptomatic primary hyperparathyroidism, 191 Scandinavian patients were assigned to parathyroidectomy or observation without surgery. Initial results, published in 2007, suggested no clinically important differences in outcomes after 2 years of follow-up (NEJM JW Gen Med Jun 15 2007 and J Clin Endocrinol Metab 2007; 92:1687). Now, the researchers have provided long-term follow-up data in two publications.

At baseline, patients' mean age was 63 (age range, 50–80), and mean serum calcium level was 10.6 mg/dL. Patients were followed annually for 10 years, during which 18% of observed patients crossed over to surgery; only three of those crossovers were due to increasing serum calciu…

Reviewing Author

Allan S. Brett, MD

Disclosures

Nothing to disclose

Allan S. Brett, MD

Disclosures

Nothing to disclose

Observation vs. Surgery for Mild Asymptomatic Primary Hyperparathyroidism

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Reviewing Author