COVID-19 Is Often Asymptomatic in Ambulatory Persons Living with HIV

Data from two cohorts of PLWH showed notable rates of SARS-CoV-2 infection (including Omicron), more than half asymptomatic.

Despite interest in the overlap between the HIV and COVID-19 epidemics, few data have addressed the likelihood of asymptomatic COVID-19 in ambulatory persons living with HIV (PLWH). Now, two studies examine that issue. Investigators in the REPRIEVE Study group obtained data about COVID-19 symptoms in a subset of participants beginning in April 2020; they also measured IgG or IgA SARS-CoV-2 anti-spike antibody levels in samples obtained from May 2020 to February 2021 (i.e., pre-Omicron). The study population consisted of 2464 PLWH (mean age, 53; median CD4 count, 649 cells/mm³; 97% had HIV RNA <400 copies/mL). Overall, 318 had a history of SARS-CoV-2 infection (58 with clinical diagnosis; 260 with serologic evidence). Of these 318 patients, …

Reviewing Author

Keith Henry, MD

Disclosures

Consultant/Advisory BoardViiV Advisory Board

Editorial BoardsJAIDS: Journal of Acquired Immune Deficiency Syndromes

Keith Henry, MD

Disclosures

Consultant/Advisory BoardViiV Advisory Board

Editorial BoardsJAIDS: Journal of Acquired Immune Deficiency Syndromes

COVID-19 Is Often Asymptomatic in Ambulatory Persons Living with HIV

Topics

Reviewing Author