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The prevalence of monoclonal gammopathy of undetermined significance (MGUS) has been examined largely in white populations of European descent. In this study, researchers examined the prevalence of MGUS in potentially higher-risk populations using mass spectrometry, a highly sensitive detection technique.
The study population of 7600 people was drawn from a U.S. screening study (PROMISE) and the Mass General Brigham Biobank; one third of participants self-identified as Black, and about half had family histories of hematologic malignancy. Most participants were between ages 30 and 70. Findings were classified as MGUS (serum monoclonal protein concentration, ≥0.2 g/L) or MGIP (monoclonal gammopathy of indeterminate potential; concentration, 0.…