CT-Based Criteria May Be Useful for Ruling in Cerebral Amyloid Angiopathy

For lobar intracerebral hemorrhages (ICHs) due to cerebral amyloid angiopathy (CAA), recurrent hemorrhage risk is substantial and can influence decision making about antithrombotic drugs. Clinical diagnoses often rely on the MRI-based modified Boston criteria. When MRI tolerability or availability is limited, a CT and APOE genotype-based prediction model for CAA, the Edinburgh criteria, has been suggested as an alternative. Given that the same resource constraints that preclude MRI might also preclude APOE genotyping, the Edinburgh investigators have now evaluated the Edinburgh CT criteria alone against the Boston criteria for probable CAA.

Of 614 consecutive patients with lobar ICH identified in a single-center registry, 210 (34%) had both …