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Growing use of preexposure prophylaxis (PrEP) among gay and bisexual men who have sex with men (MSM) has been associated with an increase in bacterial STIs. Is this because confidence in PrEP enables sexual behaviors? Investigators evaluated the direct and indirect linkages between PrEP use and bacterial STIs (Neisseria gonorrhea, Chlamydia trachomatis, and syphilis) in a cohort of MSM in three Canadian cities. Participants with HIV-negative or unknown status at baseline underwent testing for HIV and other STIs, determination of PrEP use, and assessment of sexual behaviors (e.g., number of partners, engagement in condomless anal sex [CAS] and oral sex).
During the preceding 6 months among 2009 participants, 97% reported engaging in oral sex,…