Physical and Mental Activity, Diet, and Dementia Risk

Lifestyle features are potentially modifiable risk factors for dementia. Two teams prospectively analyzed data from the U.K. Biobank study to determine dementia risk associated with patterns of physical activity and mental activity (PA/MA) and with consumption of ultraprocessed foods (UPF). In both studies, all participants were dementia-free at baseline. Physical and mental activity were determined by questionnaire data, and consumption of UPF was determined by data from at least two 24-hour dietary assessments. Covariates included demographics, socioeconomic factors, alcohol/smoking status, body-mass index, area-based deprivation, medical comorbidities, and cognitive function, with the addition of sleep duration, total energy intake, and …