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Autoimmune neurologic disease associated with septin-5 and septin-7 antibodies was described recently. Septins have diverse roles in biology, including regulating microtubules, actin, and diffusion. Investigators now describe 23 patients, of whom 17 of 18 with sera samples and all 12 with cerebrospinal fluid (CSF) samples had septin-specific immunoglobulin G (IgG) antibodies. By a cell-based assay, 15 patients were positive for septin-7, 6 for septin-5, and 2 for both.
The patients' median age was 63 (range, 40–85), and 61% were male. All patients with septin-5 antibodies had ataxia with prominent eye movement disorders. None had identifiable neoplasms. Two patients with septin-5 antibodies had cerebellar atrophy on MRI. Most patients with s…