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As SARS-CoV-2 continues to circulate and more of the population has immunity, young children constitute an increasing percentage of infections due to later approval and lower uptake of vaccine. Although children generally have milder infections, >1800 have died from COVID-19, of which 585 were younger than 5 years (CDC COVID Data Tracker).
Researchers assessed efficacy and safety of two doses of the Moderna mRNA vaccine 28 days apart in children aged 6 months–5 years. A 25-μg dose was first chosen based on its safety and immunogenicity, and children were randomized in a 3:1 ratio to receive vaccine or placebo. Key findings are as follows:
Adverse local and systemic reactions were more common in the vaccine group, but most were mild, with inje…