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Aspirin was associated with lower risk for fracture in a recent meta-analysis of observational studies (BMJ Open 2020;10:e026876); a potential mechanism could be aspirin's effect on prostaglandins, which in turn affect bone remodeling. In this substudy of the ASPREE randomized trial (NEJM JW Gen Med Oct 15 2018 and N Engl J Med 2018; 379:1499, 1509, and 1519), researchers determined associations between daily low-dose (100 mg) aspirin and risks for serious falls (i.e., falls that prompt a visit to the hospital) and fractures in 17,000 healthy older adults (median age, 74) in Australia who were randomized to receive aspirin or placebo.
After a median 4.6-year follow-up, 1700 serious falls and 2900 fractures had occurred. Risk for serious fall…