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Infection with hepatitis B virus (HBV) can be effectively treated with an oral nucleoside or nucleotide analog (NA). Still, lifelong daily medication is required and the clinical rebound that results from stopping medication can be severe. As is the case for other chronic viral infections, the holy grail of treatment would be a molecule to induce permanent remission with a delimited course of treatment. One proposed compound is the antisense nucleotide bepirovirsen, which inactivates HBV RNA in multiple capacities and limits viral protein synthesis.
In a worldwide, multicenter, manufacturer-supported, phase 2B trial, researchers randomized 457 adults with chronic HBV infection to one of four dosing schedules of weekly bepirovirsen administer…