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Patients commonly take supplements advertised to improve cardiovascular health, although the evidence to support this practice is limited. In the industry-funded Supplements, Placebo, or Rosuvastatin Study (SPORT) trial, investigators compared the efficacy for lowering low-density lipoprotein cholesterol (LDL-C) of six commonly used dietary supplements — fish oil, cinnamon, garlic, turmeric, plant sterols, and red yeast rice — with a low-dose statin and placebo.
One hundred and ninety-nine patients (mean age, 64 years; 59% women) with elevated LDL-C and increased 10-year risk of atherosclerotic cardiovascular disease identified from a single center were randomized to rosuvastatin (5 mg daily), placebo, or one of the supplements. The primary …