Does MRI Improve Accuracy of Biopsy in Prostate Cancer Screening?

MRI-directed biopsy might reduce overdiagnosis of clinically insignificant prostate cancers.

Increasingly, urologists are using magnetic resonance imaging (MRI) to inform decisions about biopsy in men who undergo prostate-specific antigen (PSA) screening for prostate cancer. Presumably, biopsies targeted to MRI abnormalities — rather than systematic but nontargeted biopsies — could reduce overdiagnosis of clinically insignificant cancers.

This Swedish trial involved 18,000 men (age range, 50–60) who had PSA screening. The 1200 men with PSA levels ≥3 ng/mL underwent MRI and were randomized to two groups. In one group, only MRI-detected abnormalities (seen in ≈40% of participants) were biopsied. In the other group, men underwent both MRI-targeted and standard systematic 12-core biopsies. Key findings were as follows:

With the overall s…

Reviewing Author

Allan S. Brett, MD

Disclosures

Nothing to disclose

Allan S. Brett, MD

Disclosures

Nothing to disclose

Does MRI Improve Accuracy of Biopsy in Prostate Cancer Screening?

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Reviewing Author