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SARS-CoV-2 vaccination is thought to protect nursing home residents, as it does the general population, but data are sparse because clinical trials were not conducted in nursing homes. Investigators linked data from a large community-based nursing home system and Veterans Health Administration (VHA) community living centers to assess the effect of vaccine boosting in long-term residents who had completed a two-dose series of mRNA vaccine and were eligible for a first booster from September to November 2021. The two cohorts included 27,000 residents, about half of whom were boosted. Residents were followed for 12 weeks after receiving boosters, or meeting inclusion criteria but not receiving boosters.
Hospitalization within 21 days of a posit…