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Dual-targeted HER2 therapy with pertuzumab and trastuzumab has shown activity in patients with HER2-amplified metastatic colorectal cancer (mCRC; NEJM JW Oncol Hematol May 2019 and Lancet Oncol 2019; 20:518).
To evaluate this approach further, investigators conducted an industry-funded, prospective, phase 2 basket trial (TAPUR) that assessed the use of pertuzumab and trastuzumab in previously treated mCRC patients who had HER2 amplification and/or HER2/3 mutation, the presence of which is seen in only 5% to 10% of mCRC patients. Of the 38 patients in the trial, 74% were HER2-amplified with or without HER2/3 mutation, 26% had only HER2/3 mutation, 68% had left-sided colon or rectal primaries, 84% had received ≥3 prior lines of therapy, and 29…