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Ketogenic diet therapies (KDTs) are high-fat, low-carbohydrate diets that have been used in patients with seizures for more than a century. KDT use in adults is limited by a lack of rigorous evidence from randomized, controlled trials showing improved seizure control. This study addressed whether the addition of a less-restrictive KDT variant, the modified Atkins diet (MAD), to ongoing standard drug therapy (SDT) improves seizure control, quality of life, and behavioral outcomes in adolescents and adults with nonsurgical drug-resistant epilepsy.
Investigators randomized 160 participants (80 adolescents and 80 adults) to either SDT plus MAD (intervention) or SDT with a normal diet (control) and assessed outcomes at 6 months. Fifty-two partici…