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Several small studies have suggested that the loop diuretic torsemide produces better outcomes than the more commonly used furosemide in patients with heart failure. However, the two agents have never been directly compared in a major clinical trial despite potentially important differences in their bioavailability and other properties. Now, investigators for the TRANSFORM-HF trial (NCT03296813) report similar 1-year outcomes with use of torsemide versus furosemide in this setting.
In this open-label, pragmatic, multicenter trial, 2859 participants hospitalized for heart failure were randomized to receive torsemide or furosemide. Recruited patients had treatment plans indicating anticipated long-term use of a loop diuretic. The primary outco…