Improved Reperfusion for Large-Vessel Stroke with Tenecteplase Compared with Alteplase

The major goal of thrombolytic therapy for acute stroke is to achieve early reperfusion. Previous studies have suggested that tenecteplase achieves reperfusion more often than alteplase does in large-vessel occlusion stroke when assessed prethrombectomy. It is unclear whether this is true across a wide range of treatment to reperfusion-assessment times, including early assessments when proceeding to thrombectomy right away as well as after the longer intervals required for interhospital transfers. To examine reperfusion rates across various assessment times, researchers pooled data from the EXTEND-IA TNK clinical trials, the EXTEND-IA trial, and the Royal Melbourne Stroke Registry, from which they identified 893 patients with large-vessel o…