Does Dietary Intervention Help in Multiple Sclerosis?

Investigators evaluated the medical literature to determine whether diet can reduce fatigue and improve quality of life in patients with multiple sclerosis (MS). Included were randomized trials of a dietary intervention in patients with definitive MS lasting a minimum of 4 weeks. Of 1828 publications identified, 12 articles reported on 11 randomized trials with a total of 608 participants. Interventions meeting inclusion criteria were Paleolithic, low-fat, Mediterranean, and anti-inflammatory diets, calorie restriction, and fasting.

The Paleolithic, Mediterranean, and low-fat diets were associated with a greater benefit in reducing fatigue compared with ketogenic, fasting, anti-inflammatory, calorie restriction, and control diets. The Paleol…