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Limited data suggest an association between lifestyle factors and memory decline, but no studies have examined the interaction between lifestyle and genetic predisposition to dementia (e.g., apolipoprotein E [APOE] ℇ4 genotype). In this study, Chinese researchers identified 29,000 people (age, ≥60; mean age, 72) with normal cognitive function and assessed their baseline status on six modifiable lifestyle factors (i.e., diet, physical exercise, smoking, drinking, cognitive activity, and social contact) and their APOE ℇ4 genotypes. Global cognitive function was assessed periodically during follow-up.
After 10 years, participants with 4 to 6 healthful lifestyle factors had significantly slower memory decline than those with unfavorable lifestyl…