Partial Oral Treatment of Uncomplicated S. aureus Bacteremia Seems Feasible

In a retrospective observational study, switching to partly oral (versus full-time intravenous) treatment did not appear to raise risk for adverse outcomes or relapse.

Current guidelines recommend at least 14 days of intravenous antibiotic therapy (IVT) for uncomplicated Staphylococcus aureus bacteremia (SAB), with longer courses for complicated cases to prevent relapse and metastatic infection (Enfermedades Infecc Microbiol Clínica Nov 2015; 33:625.e1). Partial oral treatment is effective and recommended in selected patients with endocarditis (NEJM JW Infect Dis Oct 2018 and N Engl J Med 2018 Aug 28; [e-pub]; NEJM JW Infect Dis Nov 2022 and Circulation 2022 Aug 31; [e-pub]) as well as those with SAB complicated by injection drug use (NEJM JW Infect Dis Feb 23 2023 and Clin Infect Dis 2023 Feb 1; 76:487); however, few studies have addressed partial oral treatment for uncomplicated SAB. Now, researchers in…

Reviewing Author

Thomas Glück, MD

Disclosures

Editorial BoardsConsilium Infectiorum by InfectoPharm, Infection

Thomas Glück, MD

Disclosures

Editorial BoardsConsilium Infectiorum by InfectoPharm, Infection

Partial Oral Treatment of Uncomplicated S. aureus Bacteremia Seems Feasible

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Reviewing Author