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Social health and brain reserve may affect brain heath. In this Swedish study, researchers analyzed how social health and brain reserve affected cognition in 368 dementia-free participants aged ≥60 years at baseline. Social health was categorized as poor or moderate–good based on questionnaire and interview data. Components of social health included networking, engagement, and support. Total brain tissue volume (TBTV), i.e., the sum of gray-matter and white-matter volume, approximated brain reserve. Outcomes included global cognition based on tests of episodic and semantic memory, perceptual speed, and letter and category fluency.
All participants had at least two cognitive assessments during 12 years of follow-up. In adjusted models, modera…