Worldwide Study of Cryptococcal Meningitis in Persons with HIV

Incidence of CM declined over time but varied geographically; most cases were diagnosed after initiation of ART.

Cryptococcal meningitis (CM) continues to cause morbidity and mortality throughout the world in persons with HIV infection (PWH), despite the development of effective antiretroviral therapy (ART). Although geographic studies have highlighted the impact of CM among PWH, knowledge gaps persist. Researchers performed a retrospective observational study of the International Epidemiology Databases to Evaluate AIDS (IeDEA) cohort from 1996 through 2017 using information from North America, Latin America, Asia-Pacific, East Africa, and Southern Africa.

Among 512,852 PWH who were followed, 3857 (0.7%) developed CM with a mortality of 31.6%. Incidence of CM fell from 2.56 to 0.97 per 1000 person-years between 2005 and 2015 and varied by geographic re…

Reviewing Author

Neil M. Ampel, MD

Disclosures

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesCoccidioidomycosis Study Group (Past President, Secretary, Treasurer)

Neil M. Ampel, MD

Disclosures

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesCoccidioidomycosis Study Group (Past President, Secretary, Treasurer)

Worldwide Study of Cryptococcal Meningitis in Persons with HIV

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Reviewing Author