Radiologically Isolated Syndrome Criteria

The 2009 criteria for radiologically isolated syndrome (as a potential precursor to multiple sclerosis) include 3 of 4 criteria from the 2005 dissemination in space (DIS) criteria: 1 gadolinium-enhancing (GdE) lesion or 9 T2 hyperintensities, 1 infratentorial lesion, 1 juxtacortical lesion, or 3 periventricular lesions. To examine whether meeting fewer of these criteria is associated with MS conversion, these researchers followed up on 747 subjects from 37 centers for a mean of 47 months. Lesion location for 2017 DIS criteria included periventricular, juxtacortical, infratentorial, and spinal cord locations. Of the participants, 11.4% were classified as group 1, which included 1 of 4 DIS locations, and another 22.2% were group 2, which incl…