Characteristics of Community-Onset Sepsis in the U.S.

In a retrospective cohort study, prevalence of positive blood cultures was low, resistant organisms were rarely detected, and mortality was lower when pathogens were identified.

Compared with hospital-acquired infections that progress to sepsis, community-onset sepsis appears to differ regarding patients' characteristics, pathogens involved, resistance rates, and outcomes. To better characterize community-onset sepsis, researchers conducted a retrospective cohort study of data from >147,000 inpatients (median age, 67; 54% male) treated for community-onset sepsis at 201 U.S. hospitals from 2016 to 2020. All subjects met standard sepsis criteria and had at least two sets of blood cultures and initiation of antibiotic therapy; median duration of hospital stay was eight days.

For patients with culture-negative sepsis, foci of infection were most often pulmonary (37%) and genitourinary (14%). Overall positivity rates of …

Reviewing Author

Thomas Glück, MD

Disclosures

Editorial BoardsConsilium Infectiorum by InfectoPharm, Infection

Thomas Glück, MD

Disclosures

Editorial BoardsConsilium Infectiorum by InfectoPharm, Infection

Characteristics of Community-Onset Sepsis in the U.S.

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Reviewing Author